Publications

2016

 

Zhang, H., Kamiya, N., Tsuji, T., Takeda, H., Scott, G., Rajderkar, S., Ray, M.K., Mochida, Y., Allen, B., Lefebvre, V., Hiung, I.H., Ornitz, D.M., Kunieda, T., and Mishina, Y., Elevated Fibroblast Growth Factor Signaling is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice, PLoS Genetics, 2016, Dec 27; 12(12):e1006510. doi:  10.1371/journal.pgen.1006510. eCollection 2016. PMID:  28027321.

 

Ermilov, A.N.*, Kumari, A.*, Li, L., Joiner, A.M., Grachtchouk, M.A., Allen, B.L., Dlugosz, A.A., and Mistretta, C.M., Maintenance of Taste Organs is Strictly Dependent on Epithelial Hedgehog/GLI Signaling, PLoS Genetics, 2016, Nov 28; 12(11):e1006442. doi:  10.1371/journal.pgen.1006442. eCollection 2016. PMCID:  PMC5125561.

 

Lorberbaum, D.S.*, Ramos, A.I.*, Peterson, K.A., Carpenter, B.S., De, S., Parker, D.S., Chiang, A.C.Y, Kassis, J.A., Allen, B.L., McMahon, A.P., and Barolo, S., An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/PTCH1, eLife, 2016, May 5 PMCID:  PMC4887206.

 

Allen, B.L., Spinal Cords Built to Scale, Developmental Cell, 2016, Apr 18; 37(2): 108-109; doi: 10.1016/j.devcel.2016.04.007. PMID: 27093078.

 

Coffman, L.G., Choi, Y., Mclean, K., Allen, B.L., Pasca di Magliano, M., and Buckanovich, R.J., Human Carcinoma-Associated Mesenchymal Stem Cells Promote Ovarian Cancer Chemotherapy Resistance via a BMP4/HH signaling loop, Oncotarget, 2016, Feb 9; 7(6):  6916-6932. PMCID:  PMC4872758.

 

 

2015

 

Gurdziel, K.*, Udager, A.M.*, Lorberbaum, D.S.*, Song, J.Y.*, Richards, N., Parker, D.S., Johnson, L.A., Allen, B.L.‡, Barolo, S.‡, and Gumucio, D.L.‡, Identification and validation of novel Hedgehog-responsive enhancers predicted by computational analysis of Ci/Gli binding site density, PLoS ONE, 2015, Dec 28; 10 (12):e0145225. doi:10.1371/journal.pone.0145225. eCollection 2015. PMCID: PMC4692483.

 

Joiner A.M.*, Green, W.W.*, McIntyre, J.C., Allen, B.L., Schwob, J.E., and Martens, J.R., Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium, Journal of Neuroscience, 2015, Oct 7; 35 (40):  13761-13772.  PMCID:  PMC4595624.

 

Song, J.Y., Holtz, A.M., Pinskey, J.M., and Allen, B.L.†, Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling, Developmental Biology, 2015, Jun 15; 402 (2):  239-252. PMCID:  PMC4450140.

 

Holtz, A.M., Griffiths, S.C., Davis, S.J., Bishop, B., Siebold, C., andAllen, B.L., HHIP1 is a secreted, heparan sulfate-binding Hedgehog pathway antagonist, Journal of Cell Biology, 2015, Jun 8; 209 (5):  739-758PMCID:  PMC4460154. (Featured Article; Cover Article) 

 

Carpenter, B.S., Barry, R.L., Verhey, K.J., and Allen, B.L.‡, The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function, Journal of Cell Science, 2015, Mar 1; 128 (5): 1034-1050. PMCID:  PMC4342584. (Featured Article; Cover Article) (PDF)

 

Kumari, A.*, Ermilov, A.N.*, Allen B.L., Bradley, R.M.†, Dlugosz, A.A.†, and Mistretta, C.M.†, Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation, Journal of Neurophysiology, 2015, Feb 1; 113 (3): 1034-1040. PMCID: PMC4312875. (Featured Article; APSselect article, March 2015; Featured in Dermatology Times) (PDF)

 

 

2014

 

Mathew, E., Zhang, Y., Holtz, A.M., Kane, K.T., Song, J.Y., Allen B.L.†, and Pasca di Magliano, M.†, Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling, Cell Reports, 2014, Oct 23; 9 (2): 484-494. PMCID: PMC4362534. (Recommended by Faculty of 1000) (PDF)

 

Camp, D., Hatian He, B., Li, S., Althaus, I.W., Holtz, A.M., Allen, B.L.‡, Charron, F., and van Meyel, D.J., Ihog and Boi Elicit Hedgehog Signaling via Ptc but do not aid Ptc in Sequestering the Hh Ligand, Development, 2014, Oct 14; 141 (20):  3879-3888. PMCID:  PMC4197687.

 

Takao, D., Dishinger, J.F., Kee, H.L., Pinskey, J.M., Allen, B.L., and Verhey, K.J., A Novel Assay for Clogging the Ciliary Pore Complex Distinguishes Mechanisms of Cytosolic and Membrane Protein Entry, Current Biology, 2014, Oct 6; 24 (19):  2288-2294. PMCID:  PMC4189977. (PDF)

 

Mathew, E.*, Collins, M.A.*, Fernandez-Barrena, M.G., Holtz, A.M., Yan, W., Hogan, J.O., Tata, Z. Allen B.L., Fernandez-Zapico, M.E., and Pasca di Magliano, M., The Transcription Factor GLI1 Modulates the Inflammatory Response During Pancreatic Tissue Remodeling, Journal of Biological Chemistry, 2014, Oct 3; 289 (40): 27727-27743. PMCID:  PMC4183809. (PDF)

 

 

2013

 

Holtz, A.M., Peterson, K.A., Nishi, Y., Morin, S., Song, J.Y., Charron, F., McMahon, A.P.†, and Allen, B.L.†, Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2, and HHIP1 during neural patterning, Development, 2013, Aug; 140 (16):  3423-3434. PMCID: 3737722. (Cover Article) (PDF)

 

 

2011

 

Allen, B.L.†, Song, J.Y., Izzi, L., Althaus, I.W., Kang, J.S., Charron, F., Krauss, R.S., and McMahon, A.P.†, Overlapping roles and collective requirement for the co-receptors Gas1, Cdo and Boc in Shh pathway function, Developmental Cell, 2011, Jun 14; 20 (6):  775-787. PMID: 21664576. (PDF)

 

Izzi, L., Levesque, M., Morin, S., Laniel, D., Wilkes, B.C., Mille, F., Krauss, R.S., McMahon, A.P., Allen, B.L., and Charron, F., Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation, Developmental Cell, 2011, Jun 14; 20 (6):  788-801. PMID: 21664577. (PDF)

 

 

2008

 

Chamberlain, C.E., Jeong, J., Guo, C., Allen, B.L., and McMahon, A.P., Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning, Development, 2008, Mar; 135 (6): 1097-1106. Epub 2008 Feb 13. PMID: 18272593. (PDF)

 

 

2007

 

Allen, B.L., Tenzen, T., and McMahon, A.P., The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development, Genes and Development, 2007, May 15; 21 (10): 1244-1257. PMID: 17504941. (Cover Article) (PDF)

See comment in: Sci STKE. 2007 Sep 11; 2007 (403): pe50. PMID: 17848687. (PDF)

 

* Wang, Y.*, McMahon, A.P., and Allen, B.L.*, Shifting paradigms in Hedgehog signaling, Current Opinion in Cell Biology, 2007, Apr; 19(2): 159-165. Epub 2007 Feb 15. PMID: 17303409. (PDF)

 

2006

 

Tenzen, T., Allen, B.L., Cole, F., Kang, J.S., Krauss, R.S., and McMahon, A.P., The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback networks in mice, Developmental Cell, 2006, May; 10 (5): 647-656. Epub 2006 Apr 27. PMID: 16647304. (PDF)

See comment in: Cell. 2006 May 5; 125 (3): 435-438. PMID: 16678090. (PDF)


 

2004

 

* Jasuja, R.*, Allen, B.L.*, Pappano, W.N.*, Rapraeger, A.C., and Greenspan, D.S., Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin, Journal of Biological Chemistry, 2004, Dec 3; 279 (49): 51289-51297. Epub 2004 Sep 20. PMID: 15381701. (PDF)

 

Griffith, B.R., Allen, B.L., Rapraeger, A.C., and Kiessling, L.L., A Polymer Scaffold for Protein Oligomerization, J. Am. Chem. Soc., 2004, Feb 18; 126 (6): 1608-1609. PMID: 14871072. (PDF)

 

 

2003

 

Allen, B.L., and Rapraeger, A.C., Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly, Journal of Cell Biology, 2003, Nov 10; 163 (3): 637-648. PMID: 14610064. (PDF)

 

Motamed, K., Blake, D.J., Angello, J.G., Allen, B.L., Rapraeger, A.C., Hauschka, S.D., and Sage, E.H, Fibroblast Growth Factor Receptor-1 Mediates the Inhibition of Endothelial Cell Proliferation and the Promotion of Skeletal Myoblast Differentiation by SPARC: A Role for Protein Kinase A, Journal of Cellular Biochemistry, 2003, Oct 1; 90(2): 408-423. PMID: 14505356. (PDF)

 

 

2001

 

* Allen, B.L., Filla, M.S., and Rapraeger, A.C., Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition, Journal of Cell Biology, 2001, Nov 26; 155(5): 845-857. PMID: 11724824. (PDF)

 

 

*authors contributed equally to this work