Relevant Publications:

  1. Braunstein, E.M., Qiao, T., Madison, B., Pinson, K. Dunbar, L., and Gumucio, D.L. Villin: a marker for development of the epithelial pyloric border. Dev. Dyn. 224:90-102, 2002.
  2. Madison, B., Qiao, T., Braunstein, E., Dunbar, L., and Gumucio, D.L Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J. Biol. Chem. 277:33275-33283, 2002.
  3. Rieder, G., Tessier, A.J., Qiao, X.T., Madison, B., Gumucio, D. and Merchant, J.L.: Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. J. Biol. Chem. 280:4906-12, 2005.
  4. Madison, B., Braunstein, K., Qiao, X., Kuizon, E., and Gumucio, D.: Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 132:279-89, 2005.
  5. Jones, R.G., Li, X., Gray, P.D., Kuang, J., Clayton, F., Samowitz, W.S., Madison, B.B., Gumucio, D.L. and Kuwada, S. K.: Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia and early postnatal lethality. J. Cell Biol. 175:505-14, 2006.
  6. Li X, Madison BB, Zacharias W, Kolterud A, States D, Gumucio DL: Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talkPhysiol Genomics. 29:290-301, 2007.
  7. Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH, Gumucio DL. Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterningGastroenterology. 137:618-28, 2009.
  8. Li X, Udager AM, Hu C, Qiao XT, Richards N, Gumucio DL. Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal lifeDev Dyn. 238:3205-17, 2009.
  9. Zacharias WJ, Li X, Madison BB, Kretovich K, Kao JY, Merchant JL, Gumucio DL. Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propriaGastroenterology. 138:2368-77, 2010. 



This work is supported by:

NIH P01 DK062041 (PI – J. Merchant) Regulation of intestinal cell identity (7/1/02-6/30/07). Project #1 (PI-Gumucio)

NIH R01 DK065850. “Cell:cell interactions during intestinal development” (3/1/05-2/28/010).

NIH R21 CA124589 “A cellular key to the gastric inflammation-metaplasia-carcinoma sequence?” (1/1/07-12/31/08).

T32 HD007505 “Training Program in Organogenesis” (Pre-doctoral fellowship award to William Zacharias)

The University of Michigan Center for Computational Medicine and Biology, Pilot grant award.